Using Binaries Cutter
Binaries Cutter scans your applications for unneeded parts designed for other platforms (either Intel or PowerPC). You can navigate to Binaries Cutter by expanding Fast Cleanup on the navigation bar and clicking Binaries Cutter, or by clicking View Result near Binaries Cutter in Fast Cleanup.
To scan your applications for useless parts, in Binaries Cutter click Scan. As a result a list of applications suitable both for Intel and PowerPC will appear, with the unnecessary size specified. All of them are selected by default, but you can deselect those you are not going to cut using the checkboxes or the Check/Uncheck buttons. You can also preview the application info using the Quick Look button and search for specific applications using the Filter field. To delete the parts, click Remove.
Binaries Cutter Preferences
How to set up Binaries Cutter in Preferences?Binaries Cutter Preferences